2015

 

 

Uytterhoeven V, Lauwers E, Maes I, Miskiewicz K, Melo MN, Swerts J, Kuenen S, Wittocx R, Corthout N, Marrink SJ, Munck S, Verstreken P. (2015). Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy. Neuron. 88:735-748. PMID:  26590345.

 

Dubos A, Castells-Nobau A, Meziane H, Oortveld MA, Houbaert X, Iacono G, Martin C, Mittelhaeuser C, Lalanne V, Kramer JM, Bhukel A, Quentin C, Slabbert J, Verstreken P, Sigrist SJ, Messaddeq N, Birling MC, Selloum M, Stunnenberg HG, Humeau Y, Schenck A, Herault Y. (2015). Conditional depletion of intellectual disability and Parkinsonism candidate gene ATP6AP2 in fly and mouse induces cognitive impairment and neurodegeneration. Human Molecular Genetics. 24:6736-6755. PMID: 26376863.

 

Sara Calafate, Arjan Buist, Katarzyna Miskiewicz, Vinoy Vijayan, Guy Daneels, Bart de Strooper, Joris de Wit, Patrik Verstreken and Dieder Moechars. (2015). Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation. Cell Rep. 11:1176-1183. PMID: 25981034.

 

Melissa Vos, Patrik Verstreken and Christine Klein. (2015). Stimulation of electron transport as potential novel therapy in Parkinson's disease with mitochondrial dysfunction. Biochemical Society Transactions. 43:275-279. PMID: 25849929.

 

Amaia M. Arranz, Lore Delbroek, Kristof Van Kolen, MR Guimarães, Wim Mandemakers, Guy Daneels, Samer Matta, Sara Calafate, Hambdy Shaban, Pieter Baatsen, Pieter-Jan De Bock, Kris Gevaert, Pieter Vanden Berghe, Patrik Verstreken, Bart De Strooper and Dieder Moechars. (2015). LRRK2 functions in synaptic vesicle endocytosis through a kinase-dependent mechanism. Journal of Cell Science. 128:541–552 PMID:  25501810

 

2014

 

Ana Clara Fernandes*, Valerie Uytterhoeven*, Sabine Kuenen, Yu-Chun Wang, Jan R Slabbaert, Jef Swerts, Jaroslaw Kasprowicz, Stein Aerts and Patrik Verstreken. (2014). Reduced synaptic vesicle protein degradation at lysosomes curbs TBC1D24/sky-induced neurodegeneration. Journal of Cell Biology. 207:453-462. PMID:  25422373.

 

Sven Vilain, Roeland Vanhauwaert, Ine Maes, Nils Schoovaerts, Lujia Zhou, Sandra Soukup, Raquel da Cunha, Elsa Lauwers, Marc Fiers and Patrik Verstreken P. (2014). Fast and Efficient Drosophila melanogaster Gene Knock-Ins Using MiMIC Transposons. G3. 4:2381-2387.

 

G. Romano, R. Klima, E. Buratti, P. Verstreken, FE Baralle and Fabian Feiguin. (2014). Chronological requirements of TDP-43 function in synaptic organization and locomotive control. Neurobiology of Disease. S0969-9961. [Epub ahead of print].  PMID:  25088713.

 

Katarzyna Miskiewicz*, Liya E. Jose*, Wondwossen M. Yeshaw, Jorge S. Valadas, Jef Swerts, Sebastian Munck, Fabian Feiguin, Bart Dermaut and Patrik Verstreken. (2014). HDAC6 is a Bruchpilot de-acetylase that facilitates neurotransmitter release. Cell Reports.. 10:94-102. PMID:  24981865.

 

Tom Cornelissen, Dominik Haddad, F. Wauters, Cindy Van Humbeeck, Wim Mandemakers, B. Koentjoro, C. Sue, Kris Gevaert, Bart De Strooper, Patrik Verstreken, Wim Vandenberghe. (2014). The deubiquitinase USP15 antagonizes Parkin-mediated mitochondrial ubiquitination and mitophagy. Human Molecular Genetics [Epub ahead of print]. PMID:

4852371.

 

Vanessa A. Morais, Dominik Haddad, Katleen Craessaerts, Pieter-Jan De Bock, Jef Swerts, Sven Vilain, Liesbeth Aerts, Lut Overbergh, Anne Grünewald, Philip Seibler, Christine Klein, Kris Gevaert, Patrik Verstreken, Bart De Strooper. (2014). PINK1 Loss of Function Mutations Affect Mitochondrial Complex I Activity via NdufA10 Ubiquinone Uncoupling. Science. 344:203-207. PMID:  24652937.

 

Jaroslaw Kasprowicz*, Sabine Kuenen*, Jef Swerts, Katarzyna Miskiewicz and Patrik Verstreken. (2014). Dynamin photoinactivation blocks Clathrin and α-adaptin recruitment and induces bulk membrane retrieval. The Journal of Cell Biology. 204:1141-1156.  PMID: 24662566. *equal contribution.

[F1000]

 

Sandra-Fausia Soukup and Patrik Verstreken. (2014). PIWI Protein Power Targeting Tau. Nature Neuroscience. 17:334-335. PMID: 24569826

 

Lujia Zhou, Joseph McInnes and Patrik Verstreken. (2014). Ultrafast synaptic endocytosis cycles to the center stage. Developmental Cell. 28:5-6. PMID: 24434135.

 

 

2013

 

Patrik Verstreken. (2013). Directing Traffic into the Future: How to keep synapses alive?  Developmental Cell 27:484. PMID: 24482802.

 

Joke Vandewalle, Marion Langen, Marlen Zschaetzsch, Bonnie Nijhof, Jamie M. Kramer, Hilde Brems, Marijke Bauters, Elsa Lauwers, Mohammed Srahna, Peter Marynen, Patrik Verstreken, Annette Schenck, Bassem A. Hassan, Guy Froyen. (2013).Ubiquitin ligase HUWE1 regulates axon branching through the Wnt/β-catenin pathway in a Drosophila model for intellectual disability. PLoS ONE. 8:e81791. PMID: 24303071.

 

Andrew A. Frank, Xinnan Wang, Cathy A. Collins, Avita A. Rodal, Quan Yuan, Patrik Verstreken and Dion K. Dickman. (2013). New approaches for studying synaptic development, function, and plasticity using Drosophila as a model system. Journal of Neuroscience. 33:17560-17568. PMID: 24198346.    

 

Melissa Vos, Blaise Lovisa, Ann Geens1, Vanessa A. Morais, Georges Wagnières, Hubert van den Bergh, Alec Ginggen, Bart De Strooper, Yanik Tardy and Patrik Verstreken. (2013). Near-infrared 808nm light boosts Complex IV-dependent respiration and rescues a Parkinson-related pink1 model. PLoS ONE. 8:e78562. PMID: 24244323.

 

Merel A. W. Oortveld, Shivakumar Keerthikumar, Martin Oti, Bonnie Nijhof, Ana Clara Fernandes, Korinna Kochinke, Anna Castells-Nobau, Eva van Engelen, Thijs Ellenkamp, Lilian Eshuis, Anne Galy Hans van Bokhoven, Bianca Habermann, Han G. Brunner, Christiane Zweier, Patrik Verstreken, Martijn A. Huynen and Annette Schenck. (2013). Human Intellectual Disability Genes Form Conserved Functional Modules in Drosophila. PLoS Genetics. 9:e1003911. PMID: 24204314.

 

Dominik M. Haddad, Sven Vilain, Melissa Vos, Giovanni Esposito, Samer Matta, Vera M. Kalscheuer, Katleen Craessaerts, Maarten Leyssen, Rafaella M. P. Nascimento, Angela M. Vianna-Morgante, Bart De Strooper, Hilde Van Esch, Vanessa A. Morais and Patrik Verstreken. (2013). Mutations in the X-linked intellectual disability gene Ube2a cause neuronal dysfunction and impair Parkin-dependent mitophagy. Molecular Cell. 50:831-843 PMID: 23685073.

 

Giovanni Esposito, Melissa Vos, Sven Vilain, Jef Swerts, Jorge De Sousa Valadas, Stefanie Van Meensel, Onno Schaap and Patrik Verstreken. (2013). Aconitase Causes Iron Toxicity in Drosophila pink1 Mutants. PLoS Genetics. 9: e1003478. PMID:

23637640 .

 

BW van Bon, MA Oortveld, LG Nijtmans, M Fenckova, B Nijhof, J Besseling, M Vos, JM Kramer, N de Leeuw, A Castells-Nobau, L Asztalos, E Viragh, M Ruiter, F Hofmann, L Eshuis, L Collavin, MA Huynen, Z Asztalos, P Verstreken, RJ Rodenburg, JA Smeitink, BB de Vries, A Schenck. (2013). CEP89 is required for mitochondrial metabolism and neuronal function in man and fly. Human Molecular Genetics. 22:3138-3151. PMID: 23575228.

 

Thang Manh Khuong, Ron L.P. Habets, Sabine Kuenen, Agata Witkowska, Jaroslaw Kasprowicz, Jef Swerts, Reinhard Jahn, Geert van den Bogaart and Patrik Verstreken (2013). Synaptic  PI(3,4,5)P3 is required for Syntaxin1A clustering and neurotransmitter release. Neuron 77:1097-1108.  PMID:

23522045.

 

Elsa Lauwers and Patrik Verstreken (2013). Chaperoning the synapse — NMNAT protects Bruchpilot from crashing. EMBO Reports 14:5-6. PMID: 23196365

 

 

2012

 

Lore Delbroek, Kristof Van Kolen, L. Steegmans, Raquel da Cunha, Wim Mandemakers, Guy Daneels, Pieter-Jan De Bock, J. Zhang, Kris Gevaert, Bart De Strooper, Dario R. Alessi, Patrik Verstreken and Diederik W Moechars (2012). Development of an enzyme-linked immunosorbent assay for detection of cellular and in vivo LRRK2 S935 phosphorylation. J Pharm Biomed Anal. 76C:49-58. PMID: 23313773.

 

Karolien Volders, S Scholz, Jan R Slabbaert, A C Nagel , Patrik Verstreken, John W Creemers, Patrick Callaerts, Martin Schwärzel (2012). Drosophila rugose is a functional homolog of mammalian neurobeachin and affects synaptic architecture, brain morphology, and associative learning. Journal of Neuroscience 32:15193-15204. PMID: 23100440.

 

Samer Matta, Kristof Van Kolen*, Raquel da Cunha*, Geert van den Bogaart*, Wim Mandemakers, Katarzyna Miskiewicz, Pieter-Jan De Bock, Vanessa A. Morais, Sven Vilain, Dominik Haddad, Lore Delbroek, Jef Swerts, Lucia Chavez, Giovanni Esposito, Guy Daneels, Eric Karran, Matthew Holt, Kris Gevaert, Diederik W. Moechars, Bart De Strooper^ and Patrik Verstreken^ (2012). LRRK2 controls an EndoA phosphorylation cycle in synaptic endocytosis. Neuron. 75:1008-1021. PMID:

 22998870 *equal contribution

[Preview in Neuron]

[F1000]

 

Melissa Vos, Giovanni Esposito, Janaka N. Edirisinghe, Sven Vilain, Dominik M. Haddad, Jan R. Slabbaert, Stefanie Van Meensel, Onno Schaap, Bart De Strooper, R. Meganathan, Vanessa A. Morais and Patrik Verstreken. (2012). VitaminK2 is a mitochondrial electron carrier that rescues Pink1 deficiency. Science. 336:1306-1310. PMID: 22582012

[Preview in Science]

[F1000]

 

Dickon M. Humphrey, Richard B. Parsons, Zoe N. Ludlow, Thomas Riemensperger, Giovanni Esposito, Patrik Verstreken, Howard T. Jacobs, Serge Birman and Frank Hirth. (2012). Alternative oxidase rescues mitochondria-mediated dopaminergic cell loss in Drosophila. Human Molecular Genetics. 21:2698-26712. PMID: 22398207

 

Sebastian Munck, Katarzyna Miśkiewicz, Ragna Sannerud, Silvia Adriana Menchon, Liya Jose, Rainer Heintzmann^, Patrik Verstreken^ and Wim Annaert^. (2012). Sub-diffraction imaging on standard microscopes through Photobleaching Microscopy with non-linear Processing. Journal of Cell Science. 125 (Pt 9):2257-2266. PMID:  22357945.

^ corresponding authors.

 

Sven Vilain, Giovanni Esposito, Dominik Haddad, Onno Schaap, Mariya P. Dobreva, Melissa Vos, Stefanie Van Meensel,  Vanessa A. Morais, Bart De Strooper and Patrik Verstreken. (2012). The yeast complex I equivalent NADH dehydrogenase rescues pink1 mutants. PLoS Genetics. 8: e1002456. PMID:22242018.

 

 

2011

 

Katarzyna Miśkiewicz, Liya E. Jose, André Bento-Abreu*, Marcus Fislage*, Ines Taes, Jarosław Kasprowicz, Jef Swerts, Stephan Sigrist, Wim Versées, Wim Robberecht and Patrik Verstreken. (2011). ELP3 controls active zone morphology by acetylating the ELKS family member Bruchpilot. Neuron. 72: 776-788. *equal contribution.

Check out our video abstract at the top of this page

[Preview in Neuron]

[F1000]

 

Giovanni Esposito, Clara Fernandes and Patrik Verstreken. Synaptic vesicle trafficking and Parkinson’s disease. Developmental Neurobiology. doi: 10.1002/dneu.20916.

 

Valerie Uytterhoeven*, Sabine Kuenen*, Jaroslaw Kasprowicz*, Katarzyna Miskiewicz* and Patrik Verstreken. (2011). Loss of Skywalker reveals synaptic endosomes as sorting stations for synaptic vesicle proteins. Cell. 145: 117-132*equal contribution

 

 

2010

 

Thang-Mahn Khong*, Ron L.P. Habets*, Jan Slabbaert and Patrik Verstreken. (2010). WASP is activated by phosphatidylinositol-4,5-bosphosphate to restrict synapse growth in a pathway parallel to bone morphogenetic protein signaling. Proceedings of the National Academy of Sciences. 107:17379-17384. *equal contribution

 

Erik Storkebaum, C.R. de Almodovar, M. Meens, S. Zacchigna, M. Mazzone, G. Vanhoutte, S. Vinckier, K. Miskiewicz, K. Poesen, D. Lambrechts, G.M. Janssen, G.E. Fazzi, Patrik Verstreken, J. Haigh, P.M. Schiffers, H. Rohrer, A. Van der Linden, J.G. De Mey and Peter Carmeliet (2010) Impaired Autonomic Regulation of Resistance Arteries in Mice With Low Vascular Endothelial Growth Factor or Upon Vascular Endothelial Growth Factor Trap Delivery. Circulation. 122:273-281.

 

Brett H. Graham, Zhihong Li, Erminio P. Alesii, Patrik Verstreken, Cynthia Lee, Jennifer Wang and William J. Craigen (2010) Neurologic dysfunction and male infertility in drosophila porin mutants: A new model for mitochondrial dysfunction and disease. Journal of Biological Chemistry. 285:11143-11153.

 

Bruno A. Bergmans, S. Ali M. Shariati, Ron L. Habets, Patrik Verstreken, Luc Schoonjans, Ulrike Müller, Carlos G. Dotti and Bart De Strooper. (2010). Neurons generated from APP/APLP1/APLP2 triple knockout embryonic stem cells behave normally in vitro and in vivo: lack of evidence for a cell autonomous role of APP in neuronal differentiation. Stem Cells, 28:399-406.

 

 

2009

 

Patrik Verstreken*, Tomoko Ohyama*, Claire Haueter, Ron L. Habets, Y.Q. Lin, Laura E. Swan, Cindy V. Ly, Koen J.T. Venken, Pietro De Camilli and Hugo J. Bellen (2009). Tweek, an evolutionarily conserved protein, is required for synaptic vesicle recycling. Neuron, 63:203-215. *equal contribution.

[Preview in Nature Chemical Biology]

[F1000]

 

Ching Man Choi,* Sven Vilain*, Sofie Van Kelst, Marion Langen, Nathalie De Geest, Jiekun Yan, Patrik Verstreken and Bassem A. Hassan. (2009). Conditional mutagenesis in Drosophila. Science, 324:54. *equal contribution.

 

Vanessa A. Morais, Patrik Verstreken^, Anne Röthig, Joél Smet, An Snellinx, Dominik M. Haddad, Wim Mandemakers, Rudy Van Coster, Wolfgang Wurst, Luca Scorrano and Bart De Strooper^. (2009). Parkinson’s disease mutations in PINK1 affect Complex I activity in mitochondria. EMBO Molecular Medicine, 1:99-101.

^ corresponding authors.

[CloseUp in EMBO Molecular Medicine]

 

Claire L. Simpson*, Robin Lemmens*, Katarzyna Miskiewicz,Wendy J. Broom,Valerie K. Hansen, Paul W.J. van Vught, John E. Landers,

Peter Sapp, Ludo Van Den Bosch, Joanne Knight, Benjamin M. Neale, Martin R. Turner, Jan H. Veldink, Roel A. Ophoff, Vineeta B. Tripathi1, Ana Beleza, Meera N. Shah, Petroula Proitsi, Annelies Van Hoecke, Peter Carmeliet, H. Robert Horvitz, P. Nigel Leigh, Christopher E. Shaw, Leonard H. van den Berg, Pak C. Sham, John F. Powell, Patrik Verstreken, Robert H. Brown Jr., Wim Robberecht, Ammar Al-Chalabi. (2009). Variants of the RNA polymerase II component ELP3 are associated with motor neuron degeneration. Human and Molecular Genetics, 18: 472-481.*equal contribution.

 

2008

 

Jaroslaw Kasprowicz*, Sabine Kuenen*, Ron Habets, Katarzyna Miskiewicz, Liesbet Smitz and Patrik Verstreken. (2008). Inactivation of clathrin heavy chain inhibits synaptic recycling but allows bulk membrane uptake. The Journal of Cell Biology, 182:1007-1016.*equal contribution.

[F1000]

 

 

Koen J.T. Venken*, Jaroslaw Kasprowicz*, Sabine Kuenen, Jiekun Yan, Bassem Hassan and Patrik Verstreken. (2008). Recombineering-mediated tagging of Drosophila genomic constructs for in vivo localization and acute protein inactivation. Nucleic Acids Research, 36:e114, 1-9. *equal contribution.

 

 

<2008

 

Click here for all Patrik’s publications

 

 

 

 

 

                                                                   Updated: Nov, 2015

Book Chapters

 

 

Roeland Vanhauwaert and Patrik Verstreken (2015). Parkinson’s disease. In Drosophila Models of Neurological Diseases, Experimental Neurology. ed. M. Wu, T. Lloyd. pii: S0014-4886(15)00043-6. PMID: 25708988

 

Jorge S. Valadas, Melissa Vos and Patrik Verstreken. (2014). Therapeutic strategies in Parkinson's disease: what we have learned from animal models. Ann N Y Acad Sci. doi: 10.1111/nyas.12577.  PMID: 25515068

 

 

Liya Jose*, Patrik Verstreken^ and Sven Vilain*^. (2013). Genetic screens in Drosophila and their Application in Motor Neuron Disease Models. In Drosophila Melanogaster Models of Motor Neuron Disease. ed. R. Cauchi.  pp. 185-210. * equal contribution; ^ corresponding authors

 

 

Ana Clara Fernandes*, Valerie Uytterhoeven* and Patrik Verstreken (2012). Studying synaptic transmission at the Drosophila neuromuscular junction using advanced FM 1-43 technology. In The making and un-making of neuronal circuits in Drosophila. ed. B. Hassan. Neuromethods 69:127-142.

 

 

Jan R. Slabbaert, Thang Manh Khuong and Patrik Verstreken (2012). Phosphoinositides at the neuromuscular junction of Drosophila melanogaster: a genetic approach. In Lipids Methods in Cell Biology. eds. M. Wenk, G. Di Paolo. Vol 108: 227-247. PMID:22325606

 

 

Melissa Vos*, Elsa Lauwers* and Patrik Verstreken. (2010). Synaptic mitochondria and organization of vesicle pools in health and disease. Frontiers in Synaptic Neuroscience: Synaptic Vesicle Pool Organization, eds. R. Renden and M. Hodge. 2, art. 139.  *equal contribution.

 

 

Ron L.P. Habets and Patrik Verstreken. (2010). Acute inactivation of synaptic proteins. In Drosophila Neurobiology Methods: A Laboratory Course manual. 533p, eds. S. Waddel, M. Freeman and B. Zhang. Pp. 393-406.

 

 

Liesbet Smitz and Patrik Verstreken. (2008). Synaptic vesicle endocytosis. In Molecular Mechanisms of Neurotransmitter Release. 347p, ed. Z. Wang. Pp. 207-238

 

 

 

 

 

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